ࡱ> QSNOP'` $VbjbjLULU .f.?.?%aaa8ac[fvdle"ffff&g )gz||||||$h)buzffzzffzb&ffzzzfjd R[-a^2+0[41gzmKru1g1g1gz1g1g1g[zzzz$'<%<  December 23, 2011 Responses to the Institute of Medicines report on vitamin D and calcium along with selected papers that seemed to help steer the IOMs decision Prepared by William B. Grant, Ph.D., wbgrant@infionline.net IOM (Institute of Medicine). 2011. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press.  HYPERLINK "http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx" http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx For a more complete list of papers citing the IOM report by Ross et al., go to  HYPERLINK "http://scholar.google.com/scholar?cites=9478656585097952305&as_sdt=2005&sciodt=0,5&hl=en" http://scholar.google.com/scholar?cites=9478656585097952305&as_sdt=2005&sciodt=0,5&hl=en or scholar.google.com and search Ross AC vitamin D, calcium A summary of the IOM report Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011 Jan;96(1):53-8. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 dietary reference intakes for calcium and vitamin d: what dietetics practitioners need to know. J Am Diet Assoc. 2011 Apr;111(4):524-7. Supporting documents Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, et al. (2009). Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep)(183), 1-420. (Prepared by Tufts Evidence-based Practice Center under Contract No. 290-2007-10055-I). AHRQ Publication No. 09-E015, Rockville, MD: Agency for Healthcare Research and Quality. August 2009. (http://www.ahrq.gov/downloads/pub/evidence/pdf/vitadcal/vitadcal.pdf) Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, Pschel K, Amling M. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2010 Feb;25(2):305-12. Critical responses to the IOM report and those reporting higher vitamin D requirements than in the report (90 journal publications) Anon. [Editorial] Things may not be what they seem World Nutrition August 2011, 2, 8, 301-307. Binkley N, Lewiecki EM. Vitamin D and Common Sense. J Clinical Densitometry. 2011 Apr;14(2):95-9. Bischoff-Ferrari HA. Vitamin D - role in pregnancy and early childhood. Ann Nutr Metab. 2011;59(1):17-21. Bischoff-Ferrari, H, Willett W. Comment on the IOM Vitamin D and Calcium Recommendations. For Adult Bone Health, Too Low on Vitamin Dand Too Generous on Calcium. The Nutrition Source. Harvard University, 2011. http://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/vitamin-d-fracture-prevention/ Bosomworth NJ. Mitigating epidemic vitamin D deficiency: The agony of evidence. Can Fam Physician. 2011 Jan;57(1):16-20. Boucher BJ. The 2010 recommendations of the American Institute of Medicine for daily intakes of vitamin. Public Health Nutrition. 2011 Apr;14(4):740. http://journals.cambridge.org/action/displayJournal?jid=PHN Boucher BJ. The Multiple Roles of Vitamin D in Human Health. A Mini-Review. Immun., Endoc. & Metab. Agents in Med. Chem., 2011, 11, 220-227. Boucher BJ. Should we be giving enhanced vitamin D intakes to all? J R Coll Physicians Edinb. 2011 Dec;41(4):324-7. Brenner DR, Arora P, Garcia-Bailo B, Wolever TM, Morrison H, El-Sohemy A, Karmali M, Badawi A. Plasma vitamin D levels and risk of metabolic syndrome in Canadians. Clin Invest Med. 2011 Dec 1;34(6):E377. Camargo CA Jr. Vitamin D and Cardiovascular Disease; Time for Large Randomized Trials. J Am College Cardiology 2011;58(14):1442-4. Cannell J. Era or error?, Public Health Nutrition. 2011 Apr;14(4):743. Cannell J. The FNB has failed millions. Guest Editorial. Townsend Letter. 2011 Feb/Mar 2011;(331,332):103. http://www.townsendletter.com/FebMarch2011/FebMarch2011.html Cogan E. [Vitamin D supplementation: why and how?]. Rev Med Brux. 2011 Sep;32(4):353-61. French. Dobnig H. A review of the health consequences of the vitamin D deficiency pandemic. J Neurol Sci. 2011; HYPERLINK "http://www.sciencedirect.com/science?_ob=PublicationURL&_hubEid=1-s2.0-S0022510X11X00114&_cid=271029&_pubType=JL&view=c&_auth=y&_acct=C000228598&_version=1&_urlVersion=0&_userid=10&md5=9ab16e5c88adbd2cc7f20552d0ea7ac8" 311(1-2):15-18. Ebeling PR. Routine screening for vitamin D deficiency in early pregnancy: past its due date? Med J Aust. 2011 Apr 4;194(7):332-3. Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zgel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D Is Required for IFN-{gamma}-Mediated Antimicrobial Activity of Human Macrophages. Sci Transl Med. 2011 Oct 12;3(104):104ra102. Feldman D, Pike JW, Adams JS. (eds) Introduction. Vitamin D, Third Edit. Elsevier/Academic Press. 2011:xxi-xxii. Garca Vadillo JA. [Are calcium and vitamin D supplements for everyone?: Pro]. Reumatol Clin. 2011 Sep;7 Suppl 2:34-9. Spanish. Garland CF, French CB, Baggerly LL, Heaney RP. Vitamin D Supplement Doses and Serum 25-hydroxyvitamin D in the Range Associated with Cancer Prevention. Anticancer Res 2011;31: 617-22. Gillie O. Editorial: Blinded by science, pragmatism forgotten. Public Health Nutrition. 2011 Apr;14(4):566-7. Gillie O. Vitamin D. Let the sun shine on you [Commentary] World Nutrition August 2011, 2, 8, 308-332. Obtainable at www.wphna.org Ginde A. Vitamin D intake: what advice should be given to women of childbearing age? Expert Rev. Obstet. Gynecol. 2011;6(2):115118. Giovannucci E. Vitamin D, how much is enough and how much is too much? Public Health Nutrition. 2011 Apr;14(4):740-1. Gorham ED, Garland CF. Vitamin D and the limits of randomized controlled trials. Public Health Nutrition. 2011 Apr;14(4):741-3. Grant WB. Additional strong evidence that optimal serum 25(OH)D levels are at least 75 nmol/l. Int J Epi 2011 40: 1005-1007. Grant WB. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 2011 September;65:1016-1026. Grant WB. Differences in sunshine duration and vitamin D production may explain much of the English north-south divide in mortality rates. BMJ. Rapid Responses. 21 Feb. 2011. http://www.bmj.com/content/342/bmj.d508/reply#bmj_el_250339 Grant WB. Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level; implications for meta-analyses and setting vitamin D guidelines. Dermato-Endocrinology. In press Grant WB. Is the Institute of Medicine Report on calcium and vitamin D good science? Biol Res Nurs. 2011 Apr;13(2):117-9. http://brn.sagepub.com/content/early/2011/01/10/1099800410396947.long Grant WB. The Institute of Medicine did not find the vitamin D-cancer link because it ignored ultraviolet-B dose studies. Public Health Nutrition. 2011 Apr;14(4):745-6. Grant WB. Weighing the Evidence linking UVB irradiance, vitamin D, and cancer risk. Mayo Clin Proc. 2011 Apr;86(4):362-3. Grant W. Re: Nutrition advice: The vitamin D-lemma, July 9, 2011. http://www.nature.com/news/2011/110706/full/475023a.html Grant WB. Reply: Vitamin D in oncology. Forschende Komplementrmedizin. 2011;18(6):355-6. Haddow JE, Neveux LM, Palomaki GE, Lambert-Messerlian G, Canick JA, Grenache DG, Lu J. The relationship between PTH and 25-hydroxy vitamin D early in pregnancy. Clin Endocrinol (Oxf). 2011 Apr 4. doi: 10.1111/j.1365-2265.2011.04066.x. [Epub ahead of print] Handel AE, Gillie O, Ramagopalan SV. Inequities in advice on vitamin D? QJM. 2011 Jun;104(6):547-9. Heaney RP, Grant WB, Holick MF, Amling M. The IOM Report on Vitamin D misleads. J Clin Endocrinol Metab. eLetter. (4 March 2011) http://jcem.endojournals.org/cgi/eletters/96/1/53 Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res. 2011;26(3):455-7. Heaney RP. Finding the appropriate referent for vitamin D. Public Health Nutrition. 2011 Apr;14(4):749-50. Heaney RP. Assessing vitamin D status. Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):440-4. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf). 2011 Oct 13. doi: 10.1111/j.1365-2265.2011.04261.x. [Epub ahead of print] Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES. Association between low serum 25-hydroxyvitamin d and depression in a large sample of healthy adults: the cooper center longitudinal study. Mayo Clin Proc. 2011 Nov;86(11):1050-5. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab,  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=Holick%20MF%2C%20Binkley%20NC%2C%20Bischoff-Ferrari%20HA%2C%20" \o "The Journal of clinical endocrinology and metabolism." 2011 Jul;96(7):1911-30. Holick MF. The D-batable institute of medicine report: a D-lightful perspective. Endocr Pract. 2011 Jan-Feb;17(1):143-9. Holick MF. The IOM D-lemma. Public Health Nutrition. 2011 May;14(5):939-41. Holick MF. Vitamin d: a d-lightful solution for health. J Investig Med. 2011 Aug;59(6):872-80. Holick MF. The D-Lightful Vitamin D for Child Health. JPEN J Parenter Enteral Nutr. 2011 Dec 16. [Epub ahead of print] Hollis BW. Short-term and long-term consequences and concerns regarding valid assessment of vitamin D deficiency: comparison of recent food supplementation and clinical guidance reports. Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):598-604. Hollis BW, Wagner CL. The vitamin D requirement during human lactation: the facts and IOM's utter failure. Public Health Nutrition. 2011 Apr;14(4):748-9. Hollis BW, Wagner CL. Vitamin D requirements and supplementation during pregnancy. Curr Opin Endocrinol Diabetes Obes. 2011, 18:371375 Hypponen E, Boucher B. Dietary reference intakes for vitamin D. BMJ Rapid Response. 13 Jan. 2011 http://www.bmj.com/content/341/bmj.c6998/reply#bmj_el_247954?sid=8fe2e3bf-cf21-466e-a3ea-904ffac19269 Johansson H, Odn A, Kanis J, McCloskey E, Lorentzon M, Ljunggren O, Karlsson MK, Thorsby PM, Tivesten A, Barrett-Connor E, Ohlsson C, Mellstrm D. Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden. Osteoporos Int. 2011 Oct 19. [Epub ahead of print] Katz DL. The Public Health Implications of the 2010 Dietary Guidelines; An Expert Interview With David L. Katz, MD, MPH by Janet Kim, MPH. Feb. 15, 2011. http://www.medscape.com/viewarticle/737342_6 Keet CA, McCormack MC, Peng RD, Matsui EC. Age- and atopy-dependent effects of vitamin D on wheeze and asthma. J Allergy Clin Immunol. 2011 Aug;128(2):414-416.e5. Lurie G, Matsuno RK, Wilkens LR, Thompson PJ, Ollberding NJ, Carney ME, Goodman MT. Cataract and Ovarian Carcinoma: Is the Vitamin D Hypothesis Alive? Cancer Epidemiol Biomarkers Prev. 2011 Oct 5. 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IOM endorses vitamin D, calcium only for bone health, dispels deficiency claims. JAMA. 2011 Feb 2;305(5):453-4, 456. Stolzenberg-Solomon R, Weinsterein SJ, Helzlsouer K. Three Authors Reply. Am J Epidemiol (2011) 173(4): 476-477. Szmuilowicz ED, Manson, JE. How much vitamin D should you recommend to your nonpregnant patients? OBG Management. July 2011;23(7):44-53. Tanne JH. Most Americans and Canadians get enough calcium and vitamin D, report says. BMJ 341:doi:10.1136/bmj.c6998 (Published 3 December 2010) Thacher TD, Clarke BL.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/21193656" Vitamin D insufficiency. Mayo Clin Proc. 2011;86(1):50-60. Van Belle TL, Gysemans C, Mathieu C. Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):617-32. Wang SQ, Burnett ME. Safety and efficacy of sunscreens: demystifying the debate. Photodermatol Photoimmunol Photomed. 2011 Oct;27(5):259-60. Welsh P, Peters MJ, Sattar N. Is vitamin D in rheumatoid arthritis a magic bullet or a mirage? The need to improve the evidence base prior to calls for supplementation. Arthritis Rheum. 2011 Jul;63(7):1763-9. Welsh P, Peters MJ, Sattar N. Vitamin D insufficiency. N Engl J Med. 2011 Apr 7;364(14):1378-9; author reply 1380. Witham MD. Should we be giving enhanced vitamin D intakes to all? J R Coll Physicians Edinb. 2011 Dec;41(4):327-9. http://www.gcnews.com/news/2011-05-06/Community/Winthrops_Chief_Academic_Officer_Participates_In_S.html      PAGE  PAGE 2 PPP|Q RRGSSTUoo"0[$\$^`0gd V"0[$\$^`0gdQS"0[$\$^`0gdaJ0-DM ^`0gdT07$8$H$^`0gdJ< 0^`0gdT"0[$\$^`0gdT 0^`0gd2* PPPPPPQ>Q?QcQdQeQrQsQ{Q|QQQQQQǹvcN9)h"$hJ<0J&B*CJaJmH ph"""sH )h"$hJ<0J$B*CJaJmH ph"""sH %h"$hJ<B*CJaJmH ph"""sH #h"$hJ<0J%5CJaJmH sH hJ<hJ<0JCJaJhJ<CJaJhJ<hJ<CJaJ!hJ<hJ<0JHB*CJaJphh"$hJ<0J!CJ]aJh"$hJ<0J CJ]aJh"$hJ<0JCJ]aJh"$hJ<0JCJ]aJh"$hJ<0JCJ]aJQQQQ R R R#R$R]R^RvRwRxRRRR}n}n[n}NA7hQS0JCJaJhxphQS0JCJaJhxphQS0JCJaJ$hxphQS0J>*B*CJaJphjhxphQSCJUaJhxphQSCJaJh"$hJ<0J!CJ]aJ)h"$hJ<0J+B*CJaJmH ph"""sH )h"$hJ<0J)B*CJaJmH ph"""sH )h"$hJ<0J*B*CJaJmH ph"""sH )h"$hJ<0J'B*CJaJmH ph"""sH )h"$hJ<0J(B*CJaJmH ph"""sH R S.SGSNSSSSS~TTTTTUUBUKU\UuUUUUUUUѸuiu\TuTuLAh"hpjCJaJhpjCJaJh%MCJaJh%Mh%M0JCJaJh%Mh%MCJ\aJh%Mh%MCJaJhQSCJaJh"hQS0JCJaJh"hQSCJaJh VhQS0JCJaJh VhQSCJaJh VhQSCJ\aJhQShQS0JCJaJhQShQSCJaJhQShQSCJ\aJhhaJ0JCJaJhhaJCJaJUUUUUUUUUVVVVVV V VV 3&`#$gd0 gd0 0-DM ^`0gd#[E0-DM ^`0gdT"0[$\$^`0gd V"0[$\$^`0gd%MUUUUUUUUUUUVVVVVV V VVVVVVVVVV V"V#V$Vͼysysoysydysoh80J4mHnHuhy hy0J4jhy0J4UhgOjhgOUh*h'NCJaJ j}h1ulhgO<CJUaJ jh1ulhgO<CJUaJ j;h1ulhgO<CJUaJh'NhcCJaJhcCJaJh'NCJaJhchcCJaJhpjh=0JCJaJVVV V!V"V#V$V0-DM ^`0gd#[E 3&`#$gd0 3h]hgd\Q,1h/ =!"#$% DyK Yhttp://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspxyK http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspxyX;H,]ą'cDyK Yhttp://scholar.google.com/scholar?cites=9478656585097952305&as_sdt=2005&sciodt=0,5&hl=enyK http://scholar.google.com/scholar?cites=9478656585097952305&as_sdt=2005&sciodt=0,5&hl=enyX;H,]ą'cYDyK 3http://jcem.endojournals.org/content/96/1/53/replyyK ~http://jcem.endojournals.org/content/96/1/53/replyyX;H,]ą'cDd F  3 "@@Dd d  3 2 white-dot-arrow"@@Dd F  3 "@@N@@@ NormalCJ_HaJmH sH tH d@d * Heading 1dd@&[$\$#5B*CJAKH$OJQJ\aJAphKKKf@"f * Heading 2dd@&[$\$%56B*CJ:OJQJ\]aJ:phIIIDA@D Default Paragraph FontRiR  Table Normal4 l4a (k(No List44 wFtitledd[$\$4U@4 wF Hyperlink >*ph:O: wFrprtbodydd[$\$0"0 wFauxdd[$\$O1 wFsrc OA wFjrnlNOQN {zcit-first-element cit-title0a@a0 {z HTML Cite6]4Oq4 {zcit-print-datejOj {z)cit-sep cit-sep-before-article-print-datehOh {z(cit-sep cit-sep-after-article-print-date&O& {zcit-vol*O* {z cit-issue`O` {z$cit-sep cit-sep-before-article-issue^O^ {z#cit-sep cit-sep-after-article-issue** {z cit-pages4O4 {zcit-first-page&O& {zcit-sep2O2 {z cit-last-page2O"2 Kdesc"dd[$\$828 Kdetails#dd[$\$.OA. \Bcit-vol15\LOQL \B cit-title115<CJ\aJphZOaZ \B!cit-sep cit-sep-after-article-vol(Oq( \Bcit-doi2\O\ \B"cit-sep cit-sep-before-article-doi6O6 \Bcit-online-datelOl \B*cit-sep cit-sep-before-article-online-datejOj \B)cit-sep cit-sep-after-article-online-date8^8 "$ Normal (Web),:O: ^ submitted1CJaJph6O6 #[Esource.dd[$\$bb U3=Default /7$8$H$-B*CJOJQJ^J_HaJmH phsH tH 66 U3=Pa30d B*^Jph@O@ U3=A0#5B*CJOJ QJ \^J aJph*W@!* \QStrong5\4 @24 \QFooter 3 !.)@A. \Q Page Number\OR\ b%titles5ddd[$\$5B* CJOJ QJ \aJphfe@b EHTML Preformatted76 2( Px 4 #\'*.25@9CJOJ QJ ^J aJ2q2 >unA7B*CJ^J aJphRR Pcit-auth cit-auth-type-author\\ P"cit-sep cit-sep-two-item-separator,, P site-title(O( Pcit-sep24O4 Pcit-last-page2^O^ P#cit-sep cit-sep-after-article-pages*O* T2src1 <RR |Wcit-first-element cit-sectionbb |W%cit-sep cit-sep-after-article-sectionJJ |Wcit-sep cit-sep-separatorT!T |Wcit-sep cit-sep-last-separator,O1, |W cit-title4(OA( |Wcit-vol3FQF |Wcit-ahead-of-print-date|a| |W2cit-sep cit-sep-before-article-ahead-of-print-datezqz |W1cit-sep cit-sep-after-article-ahead-of-print-date(O( {gs_a1ph0O0 { nlm_name25\*O* G d text_bold44 "linksKdd[$\$(O( (dslug-vol,O, (d slug-issueί f2./~AB~$%:@ A B ' & rs? 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